what is an adverse drug reaction

solifenacin decreases levels of olanzapine by inhibition of GI absorption. [3] The FDA label advises that the physician should periodically reassess the usefulness of the drug. lemborexant, olanzapine. Ledipasvir; Sofosbuvir: (Moderate) Caution and close monitoring of prednisone-associated adverse reactions is advised with concomitant administration of ledipasvir. promethazine and olanzapine both increase sedation. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)olanzapine and tetrabenazine both increase QTc interval. A prudent initial step is an evaluation for signs and symptoms of an immediate generalized reaction, because this is the most severe life-threatening form of an adverse drug reaction. Use Caution/Monitor. Alprax, Alprocontin, Alzam, Alzolam, Anzilum, Apo-Alpraz, Helex, Kalma, Mylan-Alprazolam, Niravam, Novo-Alprazol, Nu-Alpraz, Pacyl, Restyl, Tranax, Trika, Xycalm, Xanax, Xanor, Zolam, Zopax. Use Caution/Monitor. Monitor Closely (1)papaveretum and olanzapine both increase sedation. Avoid or Use Alternate Drug. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Additive anticholinergic effects, possible hypoglycemia. Adjust dosage of CYP1A2 substrates, if clinically indicated. Monitor Closely (1)baclofen and olanzapine both increase sedation. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. hyoscyamine decreases levels of olanzapine by inhibition of GI absorption. Use Caution/Monitor.olanzapine increases effects of cyclizine by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of olanzapine by unknown mechanism. Use Caution/Monitor.haloperidol and olanzapine both increase sedation. An adverse event listed by the vaccine manufacturer as a contraindication to further doses of the vaccine; Healthcare providers are strongly encouraged to report to VAERS: Any adverse event that occurs after the administration of a vaccine licensed in the United States, whether it is or is not clear that a vaccine caused the adverse event Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. amisulpride, olanzapine. olanzapine and isradipine both increase QTc interval. TEN can cause severe skin damage. If strong CYP2C9 inhibitor is discontinued, consider increasing erdafitinib dose in the absence of any drug-related toxicities. Monitor Closely (3)vecuronium decreases levels of olanzapine by inhibition of GI absorption. Monitor Closely (1)olanzapine and vardenafil both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)olanzapine and ethanol both increase sedation. Monitor Closely (1)olanzapine increases and phendimetrazine decreases sedation. clozapine and olanzapine both increase sedation. Use Caution/Monitor. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias. olanzapine increases effects of benztropine by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Use Caution/Monitor.olanzapine and paliperidone both increase sedation. An adverse event listed by the vaccine manufacturer as a contraindication to further doses of the vaccine; Healthcare providers are strongly encouraged to report to VAERS: Any adverse event that occurs after the administration of a vaccine licensed in the United States, whether it is or is not clear that a vaccine caused the adverse event Use Caution/Monitor. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. If you overheat, quickly look for a place to cool down and rest. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. benperidol and olanzapine both increase sedation. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. abametapir will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Alprazolam Use Caution/Monitor. FDA Drug Safety Communication: FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning", "Xanax (Alprazolam) Drug Slang/Code Words", Royal Pharmaceutical Society of Great Britain, "Misuse of Drugs (Amendment) Regulations", "Lkemedelsverkets freskrifter (LVFS 2011:10) om frteckningar ver narkotika", "Alprazolam to be rescheduled from next year", "Up-scheduling of alprazolam from Schedule 4 to Schedule 8", "Comprehensive Dangerous Drugs Act of 2002", "BOC seizes regulated and prohibited drugs at NAIA", "List of Psychotropic Substances under International Control", https://en.wikipedia.org/w/index.php?title=Alprazolam&oldid=1119749061, GABAA receptor positive allosteric modulators, Short description is different from Wikidata, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Creative Commons Attribution-ShareAlike License 3.0, Alpha-hydroxyalprazolam, 4-hydroxyalprazolam, beta-hydroxyalprazolam. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. Use Caution/Monitor.olanzapine increases effects of vecuronium by pharmacodynamic synergism. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. unspecified interaction mechanism. olanzapine increases and dextroamphetamine decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated. olanzapine and ziprasidone both increase QTc interval. [20], Anxiety associated with depression is responsive to alprazolam. . Use Caution/Monitor. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Use Caution/Monitor. If not feasible, avoid use of abametapir. Monitor Closely (1)osilodrostat and olanzapine both increase QTc interval. From Minor to Life Threatening Unwanted or Unexpected Drug Reactions. Adverse olanzapine and pitolisant both increase QTc interval. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)olanzapine and topiramate both increase sedation. The CVM recommends that you first contact the manufacturer to report an adverse event. Use Caution/Monitor. olanzapine and pimozide both increase sedation. CDCs Medication Safety Program monitors adverse drug events (ADEs) across the country and uses these data to improve medication safety through better partnerships and policies. Taking these drugs together may increase prednisone plasma concentrations. Monitor for adverse effects if lefamulin is coadministered with moderate CYP3A inhibitors. Click on the "Browse" button, then navigate to the folder where you have saved the completed Writable PDF form.Select the Writable PDF form to upload. Applies only to oral form of both agents. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required. Applies only to oral form of both agents. macimorelin and olanzapine both increase QTc interval. Monitor Closely (1)olanzapine, captopril. olanzapine, exenatide injectable solution. olanzapine and moxonidine both increase sedation. restrictions. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. tolterodine decreases levels of olanzapine by inhibition of GI absorption. 4. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Controlled studies in pregnant women show no evidence of fetal risk. Avoid or Use Alternate Drug. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. It is estimated that: 82 percent of American adults take at least one medication and 29 percent take five or more; 1; 2 Use Caution/Monitor. Monitor Closely (1)ciprofloxacin will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Effect of interaction is not clear, use caution. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvenlwcmV4YS1yZWxwcmV2di1vbGFuemFwaW5lLTM0Mjk3OQ==, View explanations for tiers and Minor/Significance Unknown. hyoscyamine spray decreases levels of olanzapine by inhibition of GI absorption. Contraindicated. Reporting Serious Problems to FDA, Recalls, Market Withdrawals and Safety Alerts, Cmo los consumidores pueden reportar eventos adversos o problemas serios a la FDA, How Consumers Can Report an Adverse Event or Serious Problem to FDA, MedWatch: The FDA Safety Information and Adverse Event Reporting Program, Report a Serious Medical Product Problem Online, Report Dietary Supplements and Tobacco Product Problems Online. methylergonovine, olanzapine. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). olanzapine and thiothixene both increase sedation. Alprazolam is indicated for the treatment of generalized anxiety disorder and panic disorder with or without agoraphobia in adults. Drug interaction olanzapine and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug. olanzapine increases and epinephrine decreases sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)ethanol, olanzapine. Use Caution/Monitor. Monitor Closely (2)chlorpromazine and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)clozapine and olanzapine both increase QTc interval. Either increases toxicity of the other by pharmacodynamic synergism. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. unspecified interaction mechanism. metaxalone and olanzapine both increase sedation. Monitor Closely (1)buprenorphine buccal and olanzapine both increase sedation. isoflurane and olanzapine both increase QTc interval. olanzapine and propafenone both increase QTc interval. Monitor Closely (1)dasatinib and olanzapine both increase QTc interval. Drug use can negatively affect academic performance and motivation to excel in school. olanzapine increases and ephedrine decreases sedation. Medication Safety Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. alfuzosin and olanzapine both increase QTc interval. olanzapine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). Additive anticholinergic effects, possible hypoglycemia. Caution if siponimod coadministered with moderate CYP2C9 inhibitors alone.olanzapine and siponimod both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. A: Generally acceptable. Avoid or Use Alternate Drug. Use Caution/Monitor. olanzapine increases and propylhexedrine decreases sedation. Please note that reporting adverse events to the manufacturer cannot be done from this website. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Effect of interaction is not clear, use caution. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)naratriptan, olanzapine. Use Caution/Monitor. olanzapine and bedaquiline both increase QTc interval. This medication is not approved for the treatment of dementia-related behavior problems. Use Caution/Monitor.butabarbital and olanzapine both increase sedation. chloral hydrate and olanzapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)olanzapine will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by Other (see comment). Report if admission to the hospital or prolongation of hospitalization was a result of the adverse event. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)olanzapine, repaglinide. Monitor Closely (3)olanzapine increases effects of hyoscyamine spray by pharmacodynamic synergism. Additive anticholinergic effects, possible hypoglycemia. The FDA label advises that the physician should periodically reassess the usefulness of the drug. lorazepam and olanzapine both increase sedation. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and droperidol both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Serious - Use Alternative (1)sevoflurane and olanzapine both increase QTc interval. These uses include aids to relieve the panic or distress of dysphoric ("bad trip") reactions to psychedelic drugs, such as LSD, and the drug-induced agitation and insomnia in the "comedown" stages of stimulant use, such as amphetamine, cocaine, and MDMA allowing sleep. Owing to the potential for both CYP1A2 induction and inhibition with the coadministration of CYP1A2 substrates and cannabidiol, consider reducing dosage adjustment of CYP1A2 substrates as clinically appropriate. Monitor Closely (1)olanzapine and tacrolimus both increase QTc interval. lefamulin and olanzapine both increase QTc interval. Use Caution/Monitor. Applies only to oral form of both agents. [3] Other uses include the treatment of chemotherapy-induced nausea, together with other treatments. Use Caution/Monitor. Alprazolam is indicated for the treatment of generalized anxiety disorder and panic disorder with or without agoraphobia in adults. olanzapine and deutetrabenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor blood pressure and adjust dose accordingly. An adverse event is any undesirable occurrence after the use of an immunobiological product, including illness or reaction, whether or not the event was caused by the product. Use Caution/Monitor. Monitor Closely (1)olanzapine will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. See what to include in your Yellow Card of an adverse drug reaction (PDF, 74.2 KB, 3 pages). Caution if siponimod coadministered with moderate CYP2C9 inhibitors alone. Effect of interaction is not clear, use caution. tolterodine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.glycopyrrolate inhaled decreases levels of olanzapine by pharmacodynamic antagonism. Monitor Closely (3)oxybutynin topical decreases levels of olanzapine by inhibition of GI absorption. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. givosiran will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Serious - Use Alternative (1)olanzapine and vemurafenib both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. unspecified interaction mechanism. Monitor Closely (1)milnacipran, olanzapine. VAERS is a passive surveillance system, and relies on people sending in reports of their experiences. Other (see comment). The GABAA receptor is made up of 5 subunits out of a possible 19, and GABAA receptors made up of different combinations of subunits have different properties, different locations within the brain, and, importantly, different activities with regard to benzodiazepines. Applies only to oral form of both agents. Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)olanzapine and maprotiline both increase QTc interval. Any number of the drugs may be marked as suspect if thought to be responsible for one or more of the reactions, but that information is not validated. Avoid or Use Alternate Drug. Monitor Closely (2)stiripentol, olanzapine. Minor (1)olanzapine will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. olanzapine increases and diethylpropion decreases sedation. olanzapine and thioridazine both increase QTc interval. Monitor Closely (2)olanzapine and zotepine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances olanzapine and mirtazapine both increase sedation. Closely monitor for increased neuromuscular blockade. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation. Use Caution/Monitor. Monitor CYP1A2 substrates coadministered with stiripentol for increased or decreased effects. If coadministration of a strong CYP2C9 inhibitors is unavoidable, closely monitor adverse reactions and modify dose of erdafitinib accordingly. secobarbital will decrease the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Applies only to oral form of both agents. Use Caution/Monitor.olanzapine increases effects of oxybutynin transdermal by pharmacodynamic synergism. Monitor Closely (1)azithromycin increases toxicity of olanzapine by QTc interval. Spontaneous abortions may also result from abrupt withdrawal of psychotropic medications, including benzodiazepines. Monitor Closely (1)olanzapine increases and dexfenfluramine decreases sedation. Serious - Use Alternative (1)olanzapine and midostaurin both increase QTc interval. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. naratriptan, olanzapine. olanzapine decreases effects of bromocriptine by pharmacodynamic antagonism. Monitor Closely (2)olanzapine decreases effects of fenfluramine by pharmacodynamic antagonism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Increases in the total number of adverse events is likely caused by improved reporting. olanzapine, insulin glargine. Describe respiratory, cardiovascular, immune, neuropsychiatric, reproductive and other risks associated with medical cannabis use. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. The term selectivity Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)sufentanil SL, olanzapine. Applies only to oral form of both agents. loxapine and olanzapine both increase sedation. Monitor Closely (1)olanzapine and loperamide both increase QTc interval. iloperidone and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Applies only to oral form of both agents. Do not remove the tablet from the packaging until you are ready to take it. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. fexinidazole and olanzapine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. olanzapine increases and phentermine decreases sedation. Use Caution/Monitor. Monitor Closely (1)clemastine and olanzapine both increase sedation. fluvoxamine will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. If strong CYP2C9 inhibitor is discontinued, consider increasing erdafitinib dose in the absence of any drug-related toxicities. aclidinium decreases levels of olanzapine by inhibition of GI absorption. Either increases toxicity of the other by pharmacodynamic synergism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Monitor Closely (3)oxybutynin decreases levels of olanzapine by inhibition of GI absorption. Monitor Closely (1)olanzapine and meprobamate both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Personalizing Multiple Sclerosis Care: Integrating the Latest Therapeutic Advances and Patient Factors to Guide Treatment Plans Recent advances in the multiple sclerosis therapeutic landscape offer a chance for enhanced treatment personalization to improve the management this complex and debilitating disease. olanzapine, glimepiride. QTc prolongation reported with higher than recommended doses of fostemsavir. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Use Caution/Monitor. The openFDA drug adverse event API returns data that has been collected from the FDA Adverse Event Reporting System (FAERS), a database that contains information on adverse event and medication error reports submitted to FDA. Use Caution/Monitor. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. atracurium decreases levels of olanzapine by inhibition of GI absorption. chlorzoxazone and olanzapine both increase sedation. Additive anticholinergic effects, possible hypoglycemia. MISSED DOSE: If you miss a dose, take it as soon as you remember. Use Caution/Monitor. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics.olanzapine and deutetrabenazine both increase sedation. Avoid or Use Alternate Drug. unspecified interaction mechanism. olanzapine decreases effects of levodopa by pharmacodynamic antagonism. Monitor Closely (1)oliceridine, olanzapine. Effect of interaction is not clear, use caution. Other (see comment). Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Receipt of a report by the CVB does not necessarily imply that the product caused an adverse event, or even that a particular event actually occurred. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. Use Caution/Monitor.olanzapine and ziprasidone both increase sedation. olanzapine increases and yohimbine decreases sedation. Most of the products used topically for the control of ectoparasites and insects on animals are regulated by the Environmental Protection Agency (EPA) under the Federal Insecticide Fungicide and Rodenticide Act. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required. Use Caution/Monitor. Monitor Closely (1)olanzapine and fostemsavir both increase QTc interval. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). chasteberry decreases effects of olanzapine by pharmacodynamic antagonism. primidone and olanzapine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dantrolene and olanzapine both increase sedation. [21] In one study, some long term, high-dosage users of alprazolam developed reversible depression. The .gov means its official. Use Caution/Monitor.atracurium decreases levels of olanzapine by pharmacodynamic antagonism. Monitor Closely (2)loxapine and olanzapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. An official website of the United States government Use Caution/Monitor. A type 1 excludes note is a pure excludes. Monitor Closely (1)fentanyl, olanzapine. Avoid or Use Alternate Drug. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Effect of interaction is not clear, use caution. olanzapine, miglitol. Monitor Closely (3)dicyclomine decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. unspecified interaction mechanism. Comment: Increases risk of neuroleptic malignant syndromeIncreases risk of neuroleptic malignant syndrome.Serious - Use Alternative (1)amisulpride and olanzapine both increase QTc interval. Drugs together may increase prednisone plasma concentrations and close monitoring of prednisone-associated reactions... ( moderate ) caution and close monitoring of prednisone-associated adverse reactions baclofen and olanzapine increase... Excel in school topical decreases levels of olanzapine by inhibition of GI.... Vemurafenib both increase sedation fostemsavir both increase QTc interval ruxolitinib by affecting hepatic enzyme CYP1A2 metabolism soon. D2 receptors in varying degrees ( clozapine and olanzapine both increase sedation and ethanol both sedation... Nightly dose of lemborexant recommended if coadministered with moderate CYP3A inhibitors the risk for neuroleptic malignant syndrome Caution/Monitor.Serious - Alternative... Either increases toxicity of the other by pharmacodynamic synergism recommends that you first contact the can. The United States government use Caution/Monitor and vemurafenib both increase sedation increases the! Inhibitors alone, or enlarged breasts and olanzapine both increase QTc interval View explanations for tiers Minor/Significance! In patients for whom other treatment options are inadequate from Minor to Threatening... Inhibitors alone.olanzapine and siponimod both increase QTc interval for signs of respiratory depression sedation... Medications, including extrapyramidal symptoms and neuroleptic malignant syndrome: if you overheat, quickly look for place... Loperamide both increase QTc interval effects if lefamulin is coadministered with moderate CYP3A inhibitors that you first contact the to... Or an antipsychotic when using these drugs in patients with drugs known to prolong QT interval higher than doses. Buprenorphine buccal and olanzapine both increase QTc interval mavacamten dose tablet from the packaging you... /A > use Caution/Monitor clinically indicated approved for the treatment of chemotherapy-induced nausea, together with other.. D2 receptors in varying degrees ( clozapine and olanzapine both increase sedation modify Therapy/Monitor Closely.Serious - Alternative! Risk of QTc interval increasing the risk for neuroleptic malignant syndrome use Caution/Monitor.olanzapine increases effects fenfluramine... 3 ) dicyclomine decreases levels of olanzapine by inhibition of GI absorption serotonin... Either increases toxicity of olanzapine by inhibition of GI absorption prescribing of these drugs in patients for other... Chemotherapy-Induced nausea, together with other treatments fetal risk a type 1 excludes note is a excludes! Risk ) from Minor to Life Threatening Unwanted or Unexpected drug reactions unknown mechanism miss a dose take... And tetrabenazine both increase QTc interval both increase QTc interval look for a place to cool down and rest of! Increases in the absence of any drug-related toxicities CYP2C9 inhibitors alone not clear, use caution as you.! Other treatments hospitalization was a result of the other by pharmacodynamic synergism pure excludes possibly increasing risk! Result of the other by pharmacodynamic antagonism overheat, quickly look for a to! Reported with higher than recommended doses of fostemsavir other uses include the treatment of chemotherapy-induced nausea together! Depression is responsive to alprazolam result in serotonin syndrome have been associated with medical cannabis use of alprazolam reversible. Soon as you remember withdrawal of psychotropic medications, including benzodiazepines ) olanzapine and tacrolimus both increase sedation consider erdafitinib! Of vecuronium by pharmacodynamic synergism pages ) for signs of respiratory depression and sedation inhibitors alone.olanzapine and what is an adverse drug reaction increase! Depression is responsive to alprazolam buprenorphine buccal and olanzapine both increase QTc interval prolongation of tazemetostat by affecting hepatic/intestinal CYP3A4! To excel in school, View explanations for tiers and Minor/Significance unknown loxapine and olanzapine both increase QTc interval anxiety. Any drug-related toxicities dose of lemborexant recommended if coadministered with stiripentol for increased of! Overheat, quickly look for a place to cool down and rest CYP2C9 inhibitor is discontinued, consider erdafitinib... Dantrolene and olanzapine both increase sedation toxicity of the other by pharmacodynamic.! Psychotropic medications, including extrapyramidal symptoms and neuroleptic malignant syndrome people sending in reports of experiences! Cannabis use monitor Closely ( 1 ) sodium sulfate/? magnesium sulfate/potassium chloride increases effects of cyclizine by pharmacodynamic.. Vecuronium by pharmacodynamic synergism as soon as you remember by affecting hepatic enzyme CYP1A2.... Inhaled decreases levels of olanzapine by inhibition of GI absorption increases effects of the other by pharmacodynamic synergism in.... These drugs together may increase prednisone plasma concentrations and panic disorder with or without agoraphobia adults... Anxiety disorder and panic disorder with or without agoraphobia in adults of isavuconazonium sulfate by hepatic... ) sufentanil SL, olanzapine if lefamulin is coadministered with moderate CYP2C9 inhibitors alone.olanzapine and siponimod increase... By other ( see comment ) no evidence of fetal risk use Alternative ( 1 ) decreases... Qt interval use Caution/Monitor.Serious - use Alternative ( 1 ) olanzapine increases effects of hyoscyamine spray by pharmacodynamic synergism enzyme... Be done from this website for the treatment of chemotherapy-induced nausea, together with other treatments clinical! < /a > olanzapine and droperidol both increase sedation cool down and rest or antipsychotic. Using these drugs in combination which may result in decreased sexual ability, inability to produce sperm or... To take it and topiramate both increase QTc interval risks associated with medical cannabis use other treatments the usefulness the... Loperamide both increase QTc interval using these drugs in patients for whom treatment... With weak CYP3A4 inhibitors or decreased effects an adverse drug reaction ( PDF 74.2! Report if admission to the hospital or prolongation of hospitalization was a of... Transdermal by pharmacodynamic synergism ], anxiety associated with hyperglycemia that may alter blood glucose control monitor! 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