Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. (This is for all dogs, not just for dog breeds at-risk for MDR1.) If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Did your research find anything about using Seresto collar for just short periods of time? Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. Thanks much for the info before I bought anything! The oral chew contains a specially optimised trio of ingredients for . That being said, I do have to give the disclaimer that Im not a veterinarian myself. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Is Frontline Plus still safe? As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. Will you be updating this article with regard to Seresto? Sarolaner is an . If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. . Simparica TRIO. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Fleas this summer in my part of CA are particularly bad. Hi, I was just wondering if you still use credelio for flea prevention? (357 reviews) Simparica. Your comment made me realize I might need to add another paragraph or two about Credelio. HEARTGARD Plus real-beef chews are the delicious, #1 vet-recommended heartworm disease preventive - and pair perfectly with #1 vet-recommended NexGard (afoxolaner) chews. Fleas were treated with effifax, active ingredient fipronil. I tried Seresto with my girl and she had a seizure. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Just want to do what is best for them? However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. And safe travels to you and Lola in the future. So now I dont know where to turn and its almost time for his monthly treatment again. Simparica. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Hi Emily, this is a great article and I appreciate all of your research! I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. It is estimated that approximately 75% of purebred Collies are affected by this mutation. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. What are your thoughts on that? There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Are you also on Instagram, by chance? He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Have you had any issues with Seresto? One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Based on my findings, Im not convinced of its superior safety. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Im trying to find out if this is safe for her. So, I now need a good flea/tick med and would rather not get another pill for her to take. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Thank you for your article. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Simparica Trio 11.1-22 lbs. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Happy to help! After logging in you can close it and return to this page. Thank you for fostering! It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. is it safe or not to use it? Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. A similar medication, Comfortis (spinosad), only treats external parasites. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Dash is MDR1 mutant/normal. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. So tick protection is also a must for us. My dogs are on Sentinel right now and Frontline Gold. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. There are other risks involving Ivermectin. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? My dog has been tested and is mutant/normal (MDR1). ? However, it did make my Collies too itchy. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! Two years ago he tested positive for lyme disease and was treated with antibiotics. Nexgard and Simparica. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Trish. Any thoughts on either of these? Best of luck with your new girl! Their lower cost makes them appealing for those of us living life on a budget, but its worth it to spend just a little more for your canines safety. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. . I didnt see the link for the drug compatibility. Thank you for the positive feedback. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. Hartz products generally dont seem to get very favorable reviews either. Is credelio considered safe when using interceptor? My Collie is double MDR1 mutant. My pleasure! While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Thank you for the reminder! Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Simparica Trio is proven to kill 5 species of ticks. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Please help! It just depends on the individual dog. Please keep me updated if you think of it! However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Congratulations and good luck with your new dog! Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. I have an Aussie mix and desperately needed some info on this. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. This May he tested positive again, but the vet thinks it could be residual from when he had it before. He was getting quite stiff and sore, but he acts like a much younger dog now. Could that have been the cause of the seizure, even though she took it more than a month ago? Also what can be used for giardia? But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. According to the Vet UK website, This product is an awesome all in one, monthly chewable tablet. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. I like Frank so much that I had to give him his own story. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Thank you for writing this article. Thanks Emily! Unfortunately, the fleas are fighting back. We will get her in about 3 weeks. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. Ive since switched to a different pain pill that is compatible with my heart pill. Congratulations on your new puppy. The vet is really no help. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. Appreciated!!! So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Your article was appreciated and helpful! We have an 11 year old tricolor rough coat collie. My other vet never brought this up when discussing my MAS. Thank you for your article. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . How can I prevent my dog from getting ticks? I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Get new post updates in monthly email newsletters. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! I doubt it as he was on leash and Im always watching him. The accidental ingestion of the product may potentially result in . Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Your thoughts? SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. (I have to give them baths with a very mild or medicated shampoo.) All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. I just took her off Sentinel Flavor Tabs. collies. Tap to zoom. Id like to have a Smooth Collie in the future. I will try to find the article again, I stupidly didnt bookmark it. My question is about Capstar. thanks for your research. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. 1 x 5mg tablet for 2.8 to 5.5 pounds. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Thank you again for all your help : ). Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Katie P. 11 days ago. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Almost time for his monthly treatment again for MDR1. these generics include Tri-Heart,. 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